Endocrine Abstracts

Background: In the classic paradigm, the primary function of sex hormone-binding globulin (SHBG) was thought to passively bind and transport steroids and estrogens in the blood to access target tissues and to determine their bioavailable fraction. Now there is increasing evidence that SHBG plays an active role in steroid actions and is an actively contributes to many age-associated comorbidities including type 2 diabetes, obesity, and metabolic syndrome (MetS).<p class="ab...

Background: Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. The OC concentration is used to assess fracture risk and monitor treatment of osteoporosis and other disorders of bone metabolism. To adequately interpret the OC concentration, it is necessary to calculate reference ranges from a healthy reference population, adapted to a specific laboratory method.Methods: We established a healthy reference p...

Objective: IGF1 has almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycaemic response. Studies showed that low and high IGF1 levels are related to impaired glucose tolerance and to a higher risk of type two diabetes. The aim of the present study was to evaluate the association between IGF1 level and insulin resistance in a Danish general population.Research Design and Methods: From the cross-sectional Health2006 stud...